What significant uprising against British settlers was led by Chief Pontiac in 1763?

The correct answer is Pontiac's Rebellion. This event, which occurred in 1763, involved a coalition of various Native American tribes under the leadership of Chief Pontiac, who sought to resist British expansion into their territories following the end of the French and Indian War. The uprising was a response to the British policies that disregarded Native American rights and issues following France's defeat and the subsequent cession of territory. Pontiac's Rebellion is significant because it highlighted the deep discontent among Native Americans toward British settlers and their encroachment on Indigenous lands, leading to a more aggressive military response from the British and ultimately shaping colonial policy in North America.

The other terms—like Pontiac's Uprising, Pontiac's War, and Pontiac's Resistance—might be used informally, but "Pontiac's Rebellion" is the historically accepted name for the event, making it the most recognized term in historical literature.